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Nextflow’s data-centric paradigm makes it ideal for bioinformatics workflows. Let’s build an RNA-seq quality control pipeline with detailed explanations of each component. 1. Pipeline Architecture Our pipeline will follow this structure: my_pipeline/ ├── main.nf # Workflow logic ├── nextflow.config #…

The fusion of large language models (LLMs) with genomic analysis pipelines enables unprecedented accuracy in variant detection. This guide demonstrates how to implement a hybrid approach combining traditional bioinformatics tools with transformer models for whole exome sequencing (WES) analysis. We’ll…

As a bioinformatics professional, you understand the challenges of balancing computational efficiency, accuracy, and scalability in software pipelines. Enter DeepSeek, a groundbreaking AI model that’s reshaping how we approach bioinformatics tool development and quality assurance. Let’s explore its transformative potential. 1.…